5-Bromo-2-oxindole → HCID 67281894, compound

HRID 1827072Notes

Reaction equation

HRID 1827072 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:30][CH3:31])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([CH3:26])=[C:24]([CH:27]=O)[NH:23][C:22]=1[CH3:29])=[O:20])[CH3:13]>>[CH2:30]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([CH3:26])=[C:24]([CH:27]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:23][C:22]=1[CH3:29])=[O:20])[CH3:31]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 207617995-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-diethylamino-propyl)-amide

Product 1

HCID 67281894HCID 67281894, compoundYield 97.2%

Procedure

5-Bromo-1,3-dihydroindol-2-one (0.5 g, 2.36 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amide (0.51 g) to give 0.84 g of the title compound as a red-orange solid.

Sources & evidence

ORD record
ord-646aec67827f4e47a530da3a54f4d87b
Source dataset
uspto-grants-2006_05
Patent number
US07053114B2

Reaction notes

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