5-Bromo-2-oxindole → HCID 67283007, compound

HRID 1827073Notes

Reaction equation

HRID 1827073 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:33][CH3:34])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[C:24]([CH:25]([CH3:27])[CH3:26])=[C:23]([CH:28]=O)[NH:22][C:21]=1[CH:30]([CH3:32])[CH3:31])=[O:19])[CH3:13]>>[CH2:33]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[C:24]([CH:25]([CH3:26])[CH3:27])=[C:23]([CH:28]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:22][C:21]=1[CH:30]([CH3:32])[CH3:31])=[O:19])[CH3:34]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586210HCID 86586210, compound

Product 1

HCID 67283007HCID 67283007, compoundYield 62.4%

Procedure

5-Bromo-1,3-dihydroindol-2-one (100 mg, 0.47 mmol) was condensed with 5-formyl-2,4-diisopropyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide (150 mg) to give 0.15 g (62%) of the title compound as a yellow-orange solid.

Sources & evidence

ORD record
ord-4f94f6fc9c6246ddba9b1f9260c2d676
Source dataset
uspto-grants-2006_05
Patent number
US07053114B2

Reaction notes

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