5-formyl-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide → HCID 67282883, compound

HRID 1827077Notes

Reaction equation

HRID 1827077 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:20][CH3:21])=[C:8]([C:10]2[CH:18]=[C:17]3[C:13]([CH2:14][C:15](=[O:19])[NH:16]3)=[CH:12][CH:11]=2)[CH:9]=1)([CH3:3])[CH3:2].[N:22]1([CH2:27][CH2:28][NH:29][C:30]([C:32]2[C:36]([CH3:37])=[C:35]([CH:38]=O)[NH:34][C:33]=2[CH3:40])=[O:31])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[N:22]1([CH2:27][CH2:28][NH:29][C:30]([C:32]2[C:36]([CH3:37])=[C:35]([CH:38]=[C:14]3[C:13]4[C:17](=[CH:18][C:10]([C:8]5[CH:9]=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=[CH:6][C:7]=5[O:20][CH3:21])=[CH:11][CH:12]=4)[NH:16][C:15]3=[O:19])[NH:34][C:33]=2[CH3:40])=[O:31])[CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 207617295-formyl-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamideHCID 21915641HCID 21915641, compound

Product 1

HCID 67282883HCID 67282883, compoundYield 75%

Procedure

6-(5-Isopropyl-2-methoxyphenyl)-1,3-dihydroindol-2-one (50 mg, 0.17 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)amide (45 mg) to give 67 mg (75%) of the title compound as an orange solid.

Sources & evidence

ORD record
ord-9ccf8a6a9c504737b91d038f2df185f9
Source dataset
uspto-grants-2006_05
Patent number
US07053114B2

Reaction notes

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