6-Chloropurine → HCID 178525138, compound

Participants

Reaction Steps

In DMF (5 mL), benzyl 4-(aminomethyl)-1-piperidinecarboxylate (1.20 g, 4.83 mmol) and 6-chloropurine (448 mg, 2.49 mmol) were combined and treated with TEA in a single portion and aged under N2 at 100° C. for 18 h. The resulting reaction was diluted with sat. NaHCO3 and extracted with ethyl acetate (3×). The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to give a brown oil which was purified by silica gel chromatography (20 g, 32–60 μm silica, 99:1:0.1 to 90:10:1 CH2Cl2:CH3OH:NH4OH) to give benzyl 4-[(9H-purin-6-ylamino)methyl]-1-piperidinecarboxylate as a brown oil.

Provenance & Evidence