HCID 9797385, compound → HCID 18732404, compound

HRID 1827129Notes

Reaction equation

HRID 1827129 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][CH2:8][CH:9]2[CH2:14][CH2:13][N:12](C(OCC3C=CC=CC=3)=O)[CH2:11][CH2:10]2)=[CH:3][CH:2]=1.[H][H]>[Pd].C(O)C>[NH:12]1[CH2:13][CH2:14][CH:9]([CH2:8][NH:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:10][CH2:11]1

Participants

5

Reactant 2

HCID 9797385HCID 9797385, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18732404HCID 18732404, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Benzyl 4-[(4-pyridinylamino)methyl]-1-piperidinecarboxylate (EXAMPLE 1) (7 g, 21 mmol) was dissolved in abs. Ethanol (150 mL) with 10% palladium on carbon (700 mg) and stirred under 1 atm of hydrogen for 2 h. The catalyst was filtered off and the filtrate was concentrated under reduced pressure to afford the N-(4-piperidinylmethyl)-4-pyridinamine as a clear oil which was used without further purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2427b68e440a482589acd185aaa8eda2
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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