Triethylamine → HCID 69414529, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.), stirred solution of 4-BOC-aminomethyl-piperidin-4-ol (0.35 g, 1.52 mmol) in dried CH2Cl2 (5 mL), under N2 was slowly added CBZ-Cl (0.24 mL, 1.67 mmol), followed by triethylamine (0.42 mL, 3.04 mmol). The ice bath was removed and the reaction solution was stirred to rt in 1 h, then concentrated in vacuo. The residue was purified by silica gel chromatography (10 CH2Cl2:1-20 IPA:89-10 hexane)) to give 4-BOC-aminomethyl-1-CBZ-piperidin-4-ol. M.S.(M+1):365.39

Provenance & Evidence