HCID 10177449, compound → HCID 22135557, compound

HRID 1827153Notes

Reaction equation

HRID 1827153 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]2[CH:24]=[C:23]([CH3:25])[N:22]=[C:21](Cl)[N:20]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:25][C:23]1[N:22]=[CH:21][N:20]=[C:19]([NH:18][CH2:17][CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH:24]=1

Participants

4

Reactant 1

HCID 10177449HCID 10177449, compound

Product 1

HCID 22135557HCID 22135557, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-[(2-chloro-6-methyl-pyrimidin-4-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester (EXAMPLE 57, 0.50 g, 1.33 mmol), Pd/C (10%, 0.05 g) in absolute ethanol (15 mL) was vigorously stirred under 1 atm H2 for 6 h. Filtered and concentrated, the reaction gave 4-[(6-methyl-pyrimidin-4-ylamino)-methyl]-piperidine. M.S.(M+1):207.30

Workup

  1. filtrationFiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-eb4088ce21d24e7fa3f8d67b80dad63e
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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