2-Chloropyrimidine-4-carboxamide → 2-{[1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amino}-pyrimidine-4-carboxylic acid amide

Participants

Role	Name	HCID	Charge
Reactant	2-Chloropyrimidine-4-carboxamide	HCID 247028	—
Reactant	[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamine	HCID 22135729	—
Product	2-{[1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amino}-pyrimidine-4-carboxylic acid amide	HCID 10222842	—

Reaction Steps

EXAMPLE 83 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 2-chloro-pyrimidine-4-carboxylic acid amide (2-chloro-pyrimidine-4-carboxylic acid amide was prepared according to G. D. Davies, D. E. O'Brien, L. R. Lewis, C. C. Cheng, J. Heterocyclic Chem., 1:130–131(1964): MS (m+1)=404.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07053089B2
Source dataset	uspto-grants-2006_05
ORD ID	ord-00dfadb6e1b848e4b75688d47017a13b
Source note	uspto-grants-2006_05