7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- → HCID 9947267, compound

HRID 1827195Notes

Reaction equation

HRID 1827195 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH2:18])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:20]1[C:21]2[CH:28]=[CH:27][NH:26][C:22]=2[N:23]=[CH:24][N:25]=1>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:20]2[C:21]3[CH:28]=[CH:27][NH:26][C:22]=3[N:23]=[CH:24][N:25]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-2×HCID 219554994-Aminomethyl-1-N-Cbz-piperidine

Product 1

HCID 9947267HCID 9947267, compound

Procedure

EXAMPLE 87 was prepared from 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester and 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (4-chloro-7H-pyrrolo[2,3-d]pyrimidine was prepared according to U. Lupke, F. Seela, Chem. Ber., 112:3832–3839(1979): MS (m+1)=366.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-28e0b4ec654948bb8f969ff5d9b2af7f
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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