4-Aminomethyl-1-N-Cbz-piperidine → HCID 10133435, compound

HRID 1827196Notes

Reaction equation

HRID 1827196 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH2:18])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:20]1[CH:25]=[CH:24][N:23]=[C:22]2[NH:26][CH:27]=[N:28][C:21]=12>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:22]2[C:21]3[N:28]=[CH:27][NH:26][C:20]=3[CH:25]=[CH:24][N:23]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 219554994-Aminomethyl-1-N-Cbz-piperidineHCID 178478247HCID 178478247, compound2×

Product 1

HCID 10133435HCID 10133435, compound

Procedure

EXAMPLE 88 was prepared from 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester and 7-chloro-3H-imidazo[4,5-b]pyridine (7-chloro-3H-imidazo[4,5-b]pyridine was prepared according to Y. Mizuno, T. Itoh, K. Saito, Chem. Pharm. Bull., 12:866–872(1964): MS (m+1)=366.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-b70cf49d485845eeb8d81296a1318ca0
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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