(3-Chloro-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine → [1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrazin-2-yl-amine

HRID 1827198Notes

Reaction equation

HRID 1827198 reaction equation
Cl[C:2]1[C:3]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([S:16]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:18])=[O:17])[CH2:12][CH2:11]2)=[N:4][CH:5]=[CH:6][N:7]=1.[H][H]>C(O)C.C(N(CC)CC)C.[Pd]>[C:21]1([CH2:20][CH2:19][S:16]([N:13]2[CH2:12][CH2:11][CH:10]([CH2:9][NH:8][C:3]3[CH:2]=[N:7][CH:6]=[CH:5][N:4]=3)[CH2:15][CH2:14]2)(=[O:18])=[O:17])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

5

Reactant 2

HCID 23577245(3-Chloro-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amineHCID 178418361HCID 178418361, compound

Product 1

HCID 23577294[1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrazin-2-yl-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 22663003EtOH triethylamineSolvent

Procedure

EXAMPLE 90 was prepared from (3-chloro-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine by hydrogenation in ethanol-triethylamine over 5% palladium on carbon, 1 atm of hydrogen: MS (m+1)=361.

Sources & evidence

ORD record
ord-8c23eab3b6d24b68b0de9f17a695ac74
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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