2-Chloro-5-fluoropyrimidin-4-amine → 5-Fluoro-N2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrimidine-2,4-diamine

HRID 1827203Notes

Reaction equation

HRID 1827203 reaction equation
[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:21]1[N:26]=[C:25]([NH2:27])[C:24]([F:28])=[CH:23][N:22]=1>>[F:28][C:24]1[C:25]([NH2:27])=[N:26][C:21]([NH:19][CH2:18][CH:15]2[CH2:14][CH2:13][N:12]([S:9]([CH2:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:10])=[O:11])[CH2:17][CH2:16]2)=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 2543722-Chloro-5-fluoropyrimidin-4-amineHCID 22135729[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamine

Product 1

HCID 235772555-Fluoro-N2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrimidine-2,4-diamine

Procedure

EXAMPLE 95 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 2-chloro-5-fluoro-pyrimidin-4-ylamine: MS (m+1)=394.5.

Sources & evidence

ORD record
ord-2daa0a0bf17c48dc92cb88d0f96b777c
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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