反应详情

2,3-Dichloropyrazine (1.0 g, 0.0067 mol), tert-butyl-4-(aminomethyl)piperidine-1-carboxylate (1.6 g, 0.0075 mol) (Astatech) and cesium carbonate (2.4 g, 0.0075 mol) in acetonitrile (10 mL) were heated to 90° C. under nitrogen for 18 h. The reaction was concentrated in vacuo, diluted with ethyl acetate (50 mL) and washed with water (50 mL). The organic extract was dried over sodium sulfate, filtered and chromatographed on silica using a gradient of 10 to 30% ethyl acetate/hexane to give the title compound as a foam. M.S.(M+1): 327.

1. concentrationThe reaction was concentrated in vacuo
2. additiondiluted with ethyl acetate (50 mL)
3. washwashed with water (50 mL)
4. extractionThe organic extract
5. dry with materialwas dried over sodium sulfate
6. filtrationfiltered
7. customchromatographed on silica using a gradient of 10 to 30% ethyl acetate/hexane