反应详情

4-[(3-Chloro-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (3.0 g, 0.0092 mol) and 0.5M sodium methoxide in methanol (40 mL) were heated under nitrogen at 75° C. for 18 h. The reaction was concentrated in vacuo, diluted with methylene chloride (100 mL) and washed with water (pH=9, adjusted with NaOH). The organic extract was dried over sodium sulfate filtered and concentrated to give the title compound. M.S.(M+1): 323.

1. concentrationThe reaction was concentrated in vacuo
2. additiondiluted with methylene chloride (100 mL)
3. washwashed with water (pH=9, adjusted with NaOH)
4. extractionThe organic extract
5. dry with materialwas dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated