Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 2-(2-Fluorophenyl)cyclopropane-1-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | (R,R)-2-(2-Fluoro-phenyl)-cyclopropanecarboxylic acid tert-butyl ester | HCID 58635344 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(2-Fluorophenyl)cyclopropane-1-carboxylic acid | HCID 21864674 | — |
반응 단계
To the t-butyl ester from Step 1 (0.52 g, 0.0022 mole) in dichloromethane at 0° C. was added trifluoroacetic acid and the mixture stirred at rt for 30 min. The reaction was concentrated in vacuo to give the title compound as an oil. Analysis of the acid by chiral HPLC (Chirapak AD, 250×4.6 mm) using 95/5(A/B), 0.2% trifluroacetic acid in hexane(A) and ethanol(B), 1 mL/min, showed the material to have a purity of ≧94% EE. M.S.(M+1): 181.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07053089B2 |
| 출처 데이터셋 | uspto-grants-2006_05 |
| ORD ID | ord-a7dcc52541f64fa89867d3352f8cf5f4 |
| 출처 메모 | uspto-grants-2006_05 |