Benzyl succinimido carbonate → 4-[(3-Methoxy-5-methyl-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester

HRID 1827226Notes

Reaction equation

HRID 1827226 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1.[CH2:18]([O:25][C:26](ON1C(=O)CCC1=O)=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]([N:15]1[CH2:16][CH2:17][CH:12]([CH2:11][NH:10][C:4]2[C:3]([O:2][CH3:1])=[N:8][C:7]([CH3:9])=[CH:6][N:5]=2)[CH2:13][CH2:14]1)=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 83172Benzyl succinimido carbonateHCID 221355914-[(3-Methoxy-5-methyl-pyrazin-2-ylamino)-methyl]-piperidine

Product 1

HCID 235772784-[(3-Methoxy-5-methyl-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester

Procedure

The above compound was prepared in a similar manner as described in EXAMPLE 130 from 4-[(3-methoxy-5-methyl-pyrazin-2-ylamino)-methyl]-piperidine using N-(benzyloxycarbonyloxy)succinimide (Sigma-Aldrich). M.S.(M+1): 371.

Workup

  1. customThe above compound was prepared in a similar manner

Sources & evidence

ORD record
ord-ecede38dec8247bbb658e7c34b284c7b
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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