HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylamine → HCID 23577267, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylamine | HCID 7622 | — |
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 2-Chloro-3-fluoropyridine | HCID 2782791 | — |
| Reactant | 4-Aminomethyl-1-N-Cbz-piperidine | HCID 21955499 | — |
| Solvent | Cyclohexanol | HCID 7966 | — |
| Product | HCID 23577267 | HCID 23577267 | — |
Reaction Steps
A mixture of 2 mmol of 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester, 1 mmol of 2-chloro-3-fluoropyridine, and 1 mmol of tributylamine were heated to reflux in 2 mL of cyclohexanol for 3 days (or 2-methoxyethanol for 14 days) under nitrogen. Preparative TLC eluting with 75:25 ether:hexane gave 4-[(3-fluoro-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07053089B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-b877d2cfdaa4428986f54df19699d8a5 |
| Source note | uspto-grants-2006_05 |