HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1827263Generated: October 27, 2026
2-Furancarbonyl chloride → (+/-)-N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinolinyl]-2-furancarboxamide
https://huagongshe.com/reaction/1827263
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2-Furancarbonyl chloride | HCID 68242 | — |
| Reactant | (+/-)-2-amino-4-(3-chlorophenyl)-alpha-(4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol | HCID 12083367 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (+/-)-N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinolinyl]-2-furancarboxamide | HCID 22136488 | — |
Reaction Steps
A mixture of (±)-2-amino-4-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol (0.00021 mol), described in International Patent Specification WO 00/39082, and 2-furancarbonyl chloride (0.00063 mol) in THF (1 ml) was heated for 5 hours at 60° C. The solvent was evaporated and the residue was purified by HPLC. The product fractions were collected and the solvent was evaporated, yielding (±)-N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinolinyl]-2-furancarboxamide, MS (ESI) m/z: 569 571 573.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07053105B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-91bd9c6890aa47eaaa6770a19afb2834 |
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| Source note | uspto-grants-2006_05 |
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