HCID 22136482, compound → HCID 10205666, compound

Participants

Reaction Steps

Raney Nickel was added at room temperature to a mixture of 4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methyl-α-[4-methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl]-6-quinolinemethanamine (0.0012 mol), obtained in Example B16, in 2-propanone (40 ml) under N2 flow. The mixture was stirred at room temperature for 3 hours, filtered over celite, rinsed with DCM and the solvent was evaporated till dryness. The residue was crystallized from diethyl ether. The precipitate was filtered off and dried. The residue (0.31 g, 52%) was purified twice by column chromatography over kromasil (eluent: CH3OH/H2O 80/20 then CH3CN/H2O 35/65; 10 μm). The pure fractions were collected and the solvent was evaporated, yielding 0.13 g (22%) of 4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methyl-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanamine, MS (ESI) m/z: 474 476 478.

Provenance & Evidence