HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1827270Generated: October 26, 2026
Isopropyl isocyanate → N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinazolinyl]-N'-(1-methylethyl)-urea
https://huagongshe.com/reaction/1827270
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropyl isocyanate | HCID 61277 | — |
| Reactant | 2-amino-4-(3-chlorophenyl)-alpha-(4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol | HCID 10227423 | — |
| Catalyst | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinazolinyl]-N'-(1-methylethyl)-urea | HCID 22136504 | 20.4% |
Reaction Steps
A mixture of 2-amino-4-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol (0.00021 mol) obtained in Example B19, and 2-isocyanato-propane (3 equiv, 0.00063 mol) in THF (1 ml) was heated at 60° C. for 5 hours. A few drops of water were added. The mixture was evaporated till dryness and purified by HPLC. The product fractions were collected and the solvent was evaporated, yielding 0.024 g (20.3%) of N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinazolinyl]-N′-(1-methylethyl)-urea, MS (ESI) m/z: 561 563 565.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07053105B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-f1f4a80a970e4cf4a3c8abdf4116d88c |
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| Source note | uspto-grants-2006_05 |
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