Hydrochloric Acid → HCID 131725774, compound

Participants

Reaction Steps

Tetrakis(triphenylphosphine)palladium(0) (173 mg, 0.15 mmol) and sodium tetrahydroborate (260 mg, 6.9 mmols) were added to an anhydrous tetrahydrofuran (20 ml) solution of the compound (23) (1.05 g, 2.3 mmols), and the mixture was stirred for 8 hours at room temperature. After 1N hydrochloric acid was added, the system was extracted with ethyl acetate 3 times. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1) to obtain colorless crystals (24) (755 mg, 79%).

Provenance & Evidence