Dichloromethane → HCID 131725776, compound

Participants

Reaction Steps

Benzoyl chloride (0.06 ml, 0.52 mmol) and anhydrous triethylamine (0.073 ml, 0.52 mmol) were added to an anhydrous dichloromethane (3 ml) solution of the compound (24) (168 mg, 0.40 mmol), and the mixture was stirred for 3 hours at room temperature. After water was added to the reaction solution, the system was extracted with ethyl acetate 3 times. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (n-hexane:ethyl acetate=7:1) to obtain a colorless oily substance (25) (209 mg, 93%).

Provenance & Evidence