Allyl bromide → HCID 131725777, compound

Participants

Reaction Steps

Allyl bromide (0.017 ml, 0.20 mmol) was added to an anhydrous acetone (16 ml) solution of the compound (28) (96 mg, 0.18 mmol), whereafter potassium carbonate (27 mg, 0.20 mmol) was added, and the mixture was stirred for 40 hours at room temperature. After the solvent was distilled off under reduced pressure, the residue was extracted with ethyl acetate 3 times. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to obtain a colorless oily substance (29) (90 mg, 87%).

Provenance & Evidence