HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1827340Generated: October 26, 2026
Succinic anhydride → N-[4-(tert-Butoxycarbonylamino-methyl)-benzyl]-succinamic acid
https://huagongshe.com/reaction/1827340
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | tert-butyl N-{[4-(aminomethyl)phenyl]methyl}carbamate | HCID 3354775 | — |
| Solvent | Citric Acid | HCID 311 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(tert-Butoxycarbonylamino-methyl)-benzyl]-succinamic acid | HCID 22137597 | 73.4% |
Reaction Steps
A mixture of the above compound (27) (2.0 g, 8.5 mmol) and succinic anhydride (0.85 g, 8.5 mmol) in DCM (50 mL) were stirred at 36° C. for several hours. The product was diluted with 5% citric acid and extracted with DCM (3×50 mL). The combined extracts were washed with brine and dried over MgSO4 to give 2.1 g (28) (72%) of the desired compound. MS (ESI−) m/z 335.23 (M−H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07053214B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-dafbe11057fe43959eaf471e84764d34 |
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| Source note | uspto-grants-2006_05 |
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