HCID 22137851, compound → 4-Aminobenzamide

HRID 1827349Notes

Reaction equation

HRID 1827349 reaction equation
ClC1C=C([NH:8][C:9](=[O:23])[C:10]2[CH:15]=[CH:14][C:13]([N:16]=[N+]=[N-])=[C:12](C(F)(F)F)[CH:11]=2)C=CC=1.[H][H]>C(O)C.[Pd]>[NH2:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([NH2:8])=[O:23])=[CH:11][CH:12]=1

Participants

5

Reactant 2

HCID 22137851HCID 22137851, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 760794-Aminobenzamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The N-3-chlorophenyl 4-azido-3-trifluoromethylbenzamide compound from Step 18c was reduced under 1 atm of hydrogen in the presence of Pd/ in ethanol to the give the corresponding 4-aminobenzamide, which was used without purification in Step 72b.

Sources & evidence

ORD record
ord-df181265695d487f81c8ff0516b509a4
Source dataset
uspto-grants-2006_05
Patent number
US07053234B2

Reaction notes

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