Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methoxy-2-methyl-3-oxopropanoic acid → N-[4-(3-Fluoro-benzyloxy)-phenyl]-2-methyl-malonamic Acid Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methoxy-2-methyl-3-oxopropanoic acid | HCID 300693 | — |
| 반응물 | 4-(3-Fluoro-benzyloxy)-phenylamine | HCID 16775314 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | N-[4-(3-Fluoro-benzyloxy)-phenyl]-2-methyl-malonamic Acid Methyl Ester | HCID 69008808 | — |
반응 단계
The title compound is prepared in analogy to example 2, starting from 4-(3-fluoro-benzyloxy)-phenylamine (as prepared in example 1b) and 2-methyl-malonic acid monomethyl ester (Nader et al., Chem. Ber. 1986, 119, 1196). Yield after flash-chromatography with dichloromethane/methanol 98:2: 40%. Colorless solid. Mp=119° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07053245B2 |
| 출처 데이터셋 | uspto-grants-2006_05 |
| ORD ID | ord-bed5bd75eb954cd09d50d747cf6c9177 |
| 출처 메모 | uspto-grants-2006_05 |