p-Fluoronitrobenzene → 1-Fluoro-4-[(4-nitrophenoxy)methyl]benzene

HRID 1827373Notes

Reaction equation

HRID 1827373 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1.[F:19]C1C=CC([N+]([O-])=O)=CC=1.FC1C=CC(CO)=CC=1>>[F:19][C:18]1[CH:17]=[CH:16][C:4]([CH2:5][O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 680224-Fluorobenzylic alcoholHCID 221379151-(3-Fluorobenzyloxy)-4-nitro-benzene

Product 1

HCID 9575111-Fluoro-4-[(4-nitrophenoxy)methyl]benzeneYield 86%

Procedure

The title compound is prepared in analogy to 1-(3-fluorobenzyloxy)-4-nitro-benzene, starting from 4-fluoro nitrobenzene and 4-fluoro benzyl alcohol. Yield: 86% of a slightly yellow solid. Mp.=124-126°.

Sources & evidence

ORD record
ord-ff720a1b373b4a259e4d083e0c130340
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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