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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1827375Generated: October 30, 2026

Methyl malonyl chloride → N-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamic Acid Methyl Ester

https://huagongshe.com/reaction/1827375

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl malonyl chlorideHCID 123460—
Reactant4-(4-Fluoro-benzyloxy)-phenylamineHCID 6486021—
ProductN-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamic Acid Methyl EsterHCID 1033595775%

Reaction Steps

The title compound is prepared in analogy to example 1 from 4-(4-fluoro-benzyloxy)-phenylamine and chlorocarbonyl-acetic acid methyl ester. Yield: 75%. Colorless solid. MS: m/e=318.2 (M++H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07053245B2
Source datasetuspto-grants-2006_05
ORD IDord-075ba73e0f2d498c8a752947ef7d514d
Source noteuspto-grants-2006_05