1-Nitro-4-{[4-(trifluoromethyl)benzyl]oxy}benzene → 4-(4-Trifluoromethyl-benzyloxy)-phenylamine

HRID 1827378Notes

Reaction equation

HRID 1827378 reaction equation
FC1C=C(C=CC=1)COC1C=CC(N)=CC=1.[F:17][C:18]([F:37])([F:36])[C:19]1[CH:35]=[CH:34][C:22]([CH2:23][O:24][C:25]2[CH:30]=[CH:29][C:28]([N+:31]([O-])=O)=[CH:27][CH:26]=2)=[CH:21][CH:20]=1>>[F:17][C:18]([F:36])([F:37])[C:19]1[CH:35]=[CH:34][C:22]([CH2:23][O:24][C:25]2[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 27437921-Nitro-4-{[4-(trifluoromethyl)benzyl]oxy}benzeneHCID 167753144-(3-Fluoro-benzyloxy)-phenylamine

Product 1

HCID 221378894-(4-Trifluoromethyl-benzyloxy)-phenylamineYield 98%

Procedure

Prepared in analogy to 4-(3-fluoro-benzyloxy)-phenylamine, by hydrogenation of 4-(4-trifluoromethyl-benzyloxy)-nitrobenzene. Yield: 98% of a slightly yellow solid. MS: m/e=268.3 (M++H).

Sources & evidence

ORD record
ord-94ce0f81d0c84ff09fc837f34ff5c21a
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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