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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1827379Generated: October 25, 2026

Methyl malonyl chloride → N-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamic Acid Methyl Ester

https://huagongshe.com/reaction/1827379

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl malonyl chlorideHCID 123460—
Reactant4-(4-Trifluoromethyl-benzyloxy)-phenylamineHCID 22137889—
ProductN-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamic Acid Methyl EsterHCID 6900755571%

Reaction Steps

In analogy to example 1, the title compound is prepared from 4-(4-trifluoromethyl-benzyloxy)-phenylamine and chlorocarbonyl-acetic acid methyl ester. Yield: 71%. Colorless solid. MS: m/e=368.1 (M++H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07053245B2
Source datasetuspto-grants-2006_05
ORD IDord-fda1cb098c974422ae6b8cc1245e8946
Source noteuspto-grants-2006_05