4-Nitrophenol → 1-Fluoro-2-[(4-nitrophenoxy)methyl]benzene

HRID 1827400Notes

Reaction equation

HRID 1827400 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14]Br>>[F:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14][O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 9804-NitrophenolHCID 67968alpha-Bromo-o-fluorotoluene

Product 1

HCID 221378901-Fluoro-2-[(4-nitrophenoxy)methyl]benzeneYield 74%

Procedure

Prepared in analogy to example 8 from 4-nitrophenol and 2-fluoro-benzylbromide. Colorless solid. Yield=74%. MS: m/e=247.1 (M+).

Sources & evidence

ORD record
ord-7564f6c714bb43d8a64489a1462952cc
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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