Nitrofungin → 2-Chloro-1-(3-fluoro-benzyloxy)-4-nitro-benzene

HRID 1827422Notes

Reaction equation

HRID 1827422 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16]Br>>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[O:11][CH2:16][C:15]1[CH:18]=[CH:19][CH:20]=[C:13]([F:12])[CH:14]=1

Participants

3

Reactant 2

HCID 12074NitrofunginHCID 680073-Fluorobenzyl bromide

Product 1

HCID 70592692-Chloro-1-(3-fluoro-benzyloxy)-4-nitro-benzeneYield 84%

Procedure

Prepared in analogy to example 8 from 2-chloro-4-nitrophenol and 3-fluoro-benzylbromide. Colorless solid. Yield=84%. MS: m/e=281.0 (M+).

Sources & evidence

ORD record
ord-43b713a12ef24eb6b0d96c53ebdf16cb
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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