Ammonia → HCID 69007404, compound

HRID 1827432Notes

Reaction equation

HRID 1827432 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[CH:10][CH:9]=1)=[O:6].[NH3:24]>CO>[F:22][C:18]1[CH:17]=[C:16]([CH:15]=[CH:14][C:11]2[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:24])=[O:2])=[CH:9][CH:10]=2)[CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 69006754HCID 69006754, compound

Product 1

HCID 69007404HCID 69007404, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared in analogy to example 3 from N-{4-[2-(3-fluoro-phenyl)-vinyl]-phenyl}-malonamic acid methyl ester and 7M ammonia in methanol. Yield=68%. Colorless solid. MS: m/e=299.2 (M++H).

Sources & evidence

ORD record
ord-340937c0dbfe4640be0d556beb04cc36
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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