HRID1827448

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：Cc1cn([C@@H]2OC(COS(C)(=O)=O)(COS(C)(=O)=O)[C@H](OCc3ccccc3)[C@H]2OS(C)(=O)=O)c(=O)[nH]c1=O

HCID10651405

未命名化合物

PRODUCTS

生成物

结构：Cc1cn([C@@H]2O[C@]3(CO)CO[C@H]2[C@H]3OCc2ccccc2)c(=O)[nH]c1=O

HCID10760978

未命名化合物

收率 44%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID19096565

未命名化合物

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

To a solution of nucleoside 11 (329 mg, 0.54 mmol) in ethanol/water (10 cm3, 1:1, v/v) was added 6M NaOH (aq) (0.9 ml, 5.4 mmol). The mixture was refluxed at 80° C. for 43 h followed by evaporation to dryness under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane/methanol (2.4% methanol, v/v) as eluent to afford nucleoside 12 (85 mg, 44%). δC ((CD3)2SO) 163.8, 150.3, 138.0, 135.8, 128.3, 127.7, 127.5, 108.0, 90.2, 86.5, 86.4, 79.3, 76.5, 72.5, 71.2, 57.2, 40.2, 40.0, 39.8. 39.6, 39.4, 39.2, 39.0, 12.3.

WORKUP

后处理

customfollowed by evaporation to dryness under reduced pressure
customThe residue was purified by silica gel column chromatography