反应详情

An argon filled flask was charged with (4-Chloro-2-nitro-phenyl)-acetic acid methyl ester (40 g, 175 mmol), 10% Pd/C (2.5 g), acetic anhydride (64 mL, 677 mmol), water (9 mL) and acetic acid (150 mL). The flask was vacuum flushed with hydrogen gas at 30 PSI and shook vigorously. After 2 hours, more 10% Pd/C (2 g) was added, and the reaction was complete after a total of 4 hours reaction time. The 10% Pd/C was removed by filtration, and the solvent was removed by rotary evaporation.

1. customflushed with hydrogen gas at 30 PSI
2. additionmore 10% Pd/C (2 g) was added
3. customafter a total of 4 hours reaction time
4. customThe 10% Pd/C was removed by filtration
5. customthe solvent was removed by rotary evaporation