HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 23577857, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 22136534 | HCID 22136534 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23577857 | HCID 23577857 | 42% |
Reaction Steps
To a solution of 6-(2-Methoxycarbonyl-phenylamino)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxylic acid (0.50 g, 1.27 mmol) in DMF was added triethylamine (0.42 mL, 3.04 mmol), methylamine (1.9 mL, 3.81 mmol), and HATU (0.578 g, 1.52 mmol). The reaction was stirred for 3 hours and then concentrated by rotary evaporation. The crude oil was chromatographed (50 g silica gel, 25–50% EtOAc/hexanes) to yield the desired product (214 mg, 42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07053107B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-114204fc88f04b03bb18e56ff67060fe |
| Source note | uspto-grants-2006_05 |