Acetic Acid → HCID 178524307, compound

Participants

Reaction Steps

A solution of 2-[3-Pyridin-2-ylethynyl- -(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-6-ylamino]-benzoic acid (231 mg, 0.477), 1M tetrabutylammonium fluoride in THF (3.8 mL, 3.816 mmol), and ethylenediamine (127 μL, 1.908 mmol), were stirred in an oil bath at 80 deg C. for 6 h. The reaction was quenched with acetic acid (218 μL, 3.816 mmol), diluted with water, and extracted with EtOAc (10×50 mL). The combined organics were washed with brine and dried over MgSO4. After concentrating a solid forms which was triturated with CH2Cl2, giving the product as a yellow powder (124 mg, 73%). ESIMS M−H−): 353.0.

Provenance & Evidence