HCID 22136507, compound → HCID 69353514, compound

HRID 1827485Notes

Reaction equation

HRID 1827485 reaction equation
[C:1]([Si:5]([CH3:13])([CH3:12])[O:6][CH2:7][C:8]#[C:9][CH2:10][NH2:11])([CH3:4])([CH3:3])[CH3:2].[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[N:18]=[C:17]([CH:22]=[CH:23][C:24]2[C:32]3[C:27](=[CH:28][C:29]([NH:33][C:34]4[CH:42]=[CH:41][CH:40]=[CH:39][C:35]=4[C:36](O)=[O:37])=[CH:30][CH:31]=3)[N:26]([CH:43]3[CH2:48][CH2:47][CH2:46][CH2:45][O:44]3)[N:25]=2)[CH:16]=1>O>[C:1]([Si:5]([CH3:13])([CH3:12])[O:6][CH2:7][C:8]#[C:9][CH2:10][NH:11][C:36](=[O:37])[C:35]1[CH:39]=[CH:40][CH:41]=[CH:42][C:34]=1[NH:33][C:29]1[CH:28]=[C:27]2[C:32]([C:24]([CH:23]=[CH:22][C:17]3[CH:16]=[C:15]([CH3:14])[CH:20]=[C:19]([CH3:21])[N:18]=3)=[N:25][N:26]2[CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][O:44]2)=[CH:31][CH:30]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 22136507HCID 22136507, compoundHCID 69353735HCID 69353735, compound

Product 1

HCID 69353514HCID 69353514, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared in a similar manner to that described for Example 33(a) step (v), in U.S. Pat. No. 6,531,491, issued Mar. 11, 2003, herein incorporated by reference in its entirety for all purposes, except using 4-(tert-Butyl-dimethyl-silanyloxy)-but-2-ynylamine and 2-[3-[2-(4,6-Dimethyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid. 1H NMR (DMSO-d6) δ 9.56 (1H, s), 9.01 (1H, t, J=5.7 Hz), 8.06 (1H, d, J=8.7 Hz), 7.81 (1H, d, J=16.4 Hz), 7.66 (1H, d, J=7.5 Hz), 7.41 (4H, m), 7.32 (1H, s), 7.09 (1H, dd, J=1.8, 8.7 Hz), 6.98 (1H, s), 6.89 (1H, t, J=8.0 Hz), 5.79 (1H, dd, J=2.4, 9.2 Hz), 4.28 (2H, s), 4.09 (2H, m), 3.86(1H,m), 3.72 (1H, m), 2.46 (3H, s), 2.42 (1H, m), 2.30 (3H, s), 2.08 (2H, m), 1.74 (1H, m), 1.57 (2H, m), 0.80 (9H, s), 0.03 (6H, s). Anal. Calcd for C38H47N5O3Si. 0.7 H2O: C, 68.89; H, 7.36; N, 10.57. Found: C, 68.99; H, 7.36; N, 10.21.

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-f979418135414112b2dd9cf0c23e8153
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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