HCID 22136558, compound → HCID 69354196, compound

HRID 1827488Notes

Reaction equation

HRID 1827488 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH:9]=[CH:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH:20][C:21]4[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=4[C:23]([OH:25])=O)=[CH:17][CH:18]=3)[N:13]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][O:31]3)[N:12]=2)[CH:3]=1.[CH:36]1([C:39]#[C:40][CH2:41][NH2:42])[CH2:38][CH2:37]1>>[CH:36]1([C:39]#[C:40][CH2:41][NH:42][C:23](=[O:25])[C:22]2[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=2[NH:20][C:16]2[CH:15]=[C:14]3[C:19]([C:11]([CH:10]=[CH:9][C:4]4[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[N:5]=4)=[N:12][N:13]3[CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][O:31]3)=[CH:18][CH:17]=2)[CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 22136558HCID 22136558, compoundHCID 69353735HCID 69353735, compound

Product 1

HCID 69354196HCID 69354196, compound

Procedure

Was prepared in a similar manner to that described for Example 6 above, except using 2-[3-[2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid E and 3-Cyclopropyl-prop-2-ynylamine. 1H NMR (CDCl3): δ 9.51 (1H, s), 7.97 (1H, d, J=8.7 Hz), 7.81 (1H, d, J=16.6 Hz), 7.51–7.42 (3H, m), 7.34–7.29 (2H, m), 7.16 (1H, s), 7.11 (1H, dd, J=9.0,1.9 Hz), 6.85 (1H, s), 6.81 (1H, dt, J=7.2, 1.1 Hz), 6.23 (1H, t, J=7.2 Hz), 5.61 (1H, dd, J=9.0, 2.6 Hz), 4.17 (2H, dd, J=5.3, 2.3 Hz), 4.07–4.00 (1H, m), 3.75–3.66 (1H, m), 2.63–2.50 (1H, m), 2.54 (3H, s), 2.32 (3H, s), 2.20–2.02 (2H, m), 1.79–1.62 (3H, m), 1.29–1.19 (1H, m), 0.77–0.67 (4H, m).

Workup

  1. customWas prepared in a similar manner to that

Sources & evidence

ORD record
ord-d21b9f4e2e354b468d51491c16e4aef2
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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