HCID 23577851, compound → HCID 9891878, compound

HRID 1827490Notes

Reaction equation

HRID 1827490 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[N:16]=[C:15]([CH:20]=[CH:21][C:22]2[C:30]3[C:25](=[CH:26][C:27]([NH:31][C:32]4[CH:40]=[CH:39][CH:38]=[CH:37][C:33]=4[C:34]([OH:36])=O)=[CH:28][CH:29]=3)[NH:24][N:23]=2)[CH:14]=1.[NH2:41][CH2:42][C:43]#[C:44][CH2:45][O:46][C:47](=[O:49])[CH3:48]>>[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[N:16]=[C:15](/[CH:20]=[CH:21]/[C:22]2[C:30]3[C:25](=[CH:26][C:27]([NH:31][C:32]4[CH:40]=[CH:39][CH:38]=[CH:37][C:33]=4[C:34]([NH:41][CH2:42][C:43]#[C:44][CH2:45][O:46][C:47](=[O:49])[CH3:48])=[O:36])=[CH:28][CH:29]=3)[NH:24][N:23]=2)[CH:14]=1

Participants

3

Reactant 2

HCID 23577851HCID 23577851, compoundHCID 86606591HCID 86606591, compound

Product 1

HCID 9891878HCID 9891878, compound

Procedure

Prepared in a similar manner to that described for Example 6 above, except using 2-[3-[2-(4,6-dimethyl-pyridin-2-yl)-vinyl] 1H-indazol-6-ylamino]-benzoic acid p-toluene sulfonate and Acetic acid 4-amino-but-2-ynyl ester. 1H NMR (CD3CN): δ 11.00 (1H, bs), 9.59 (1H, s), 7.99 (1H, d, J=8.6 Hz), 7.86 (1H, d, J=16.4 Hz), 7.58 (1H, d, J=7.8 Hz), 7.49–7.37 (4H, m), 7.32 (1H,s ), 7.21 (1H, s), 7.06 (1H, dd, J=8.8, 1.8 Hz), 6.96 (1H, s), 6.90 (1H, t, J=7.8 Hz), 4.63 (2H, s), 4.16 (2H, d, J=5.6 Hz), 2.49 (3H, s), 2.32 (3H, s), 2.01 (3H, s).

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-870cd9175767436b92164bee3918d91c
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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