反应详情

Prepared in a similar manner to that described for Example 6 above, except using 2-[3-[2-(4-methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid and 3-Cyclopropyl-prop-2-ynylamine. 1H NMR (DMSO-d6): δ 9.88 (1H, bs), 8.93 (1H, bt), 8.46 (1H, d, J=4.9 Hz), 8.08 (1H, d, J=8.7 Hz), 7.85 (1H, d, J=16.4 Hz), 7.69 (1H, d, J=7.6 Hz), 7.54–7.40 (5H, m), 7.14–7.11 (2H, m), 6.90 (1H, t, J=6.1 Hz), 5.81 (1H, d, J=7.5 Hz), 4.02 (2H, d, J=3.6 Hz), 3.95–3.85 (1H, m), 3.79–3.72 (1H, m), 2.49–2.35 (1H, m), 2.35 (3H, s), 2.15–2.01 (2H, m), 1.87–1.55 (3H, m), 1.30–1.25 (1H, m), 0.77–0.70 (2H, m), 0.59–0.54 (2H, m).

1. customPrepared in a similar manner to that