HCID 22136558, compound → HCID 69355100, compound

HRID 1827494Notes

Reaction equation

HRID 1827494 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[CH:9][C:10]2[C:18]3[C:13](=[CH:14][C:15]([NH:19][C:20]4[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=4[C:22](O)=[O:23])=[CH:16][CH:17]=3)[N:12]([CH:29]3[CH2:34][CH2:33][CH2:32][CH2:31][O:30]3)[N:11]=2)[CH:3]=1.[CH:35]1([C:38]#[C:39][CH2:40][NH2:41])[CH2:37][CH2:36]1>>[CH:35]1([C:38]#[C:39][CH2:40][NH:41][C:22](=[O:23])[C:21]2[CH:25]=[CH:26][CH:27]=[CH:28][C:20]=2[NH:19][C:15]2[CH:14]=[C:13]3[C:18]([C:10]([CH:9]=[CH:8][C:4]4[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=4)=[N:11][N:12]3[CH:29]3[CH2:34][CH2:33][CH2:32][CH2:31][O:30]3)=[CH:17][CH:16]=2)[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 22136558HCID 22136558, compoundHCID 693525322-[3-[2-(4-Methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid

Product 1

HCID 69355100HCID 69355100, compound

Procedure

Prepared in a similar manner to that described for Example 6 above, except using 2-[3-[2-(4-methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid and 3-Cyclopropyl-prop-2-ynylamine. 1H NMR (DMSO-d6): δ 9.88 (1H, bs), 8.93 (1H, bt), 8.46 (1H, d, J=4.9 Hz), 8.08 (1H, d, J=8.7 Hz), 7.85 (1H, d, J=16.4 Hz), 7.69 (1H, d, J=7.6 Hz), 7.54–7.40 (5H, m), 7.14–7.11 (2H, m), 6.90 (1H, t, J=6.1 Hz), 5.81 (1H, d, J=7.5 Hz), 4.02 (2H, d, J=3.6 Hz), 3.95–3.85 (1H, m), 3.79–3.72 (1H, m), 2.49–2.35 (1H, m), 2.35 (3H, s), 2.15–2.01 (2H, m), 1.87–1.55 (3H, m), 1.30–1.25 (1H, m), 0.77–0.70 (2H, m), 0.59–0.54 (2H, m).

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-b1ee38106105439eb3d393c609f08049
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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