HCID 22136507, compound → HCID 69354000, compound

HRID 1827499Notes

Reaction equation

HRID 1827499 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[CH:9][C:10]2[C:18]3[C:13](=[CH:14][C:15]([NH:19][C:20]4[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=4[C:22](O)=[O:23])=[CH:16][CH:17]=3)[N:12]([CH:29]3[CH2:34][CH2:33][CH2:32][CH2:31][O:30]3)[N:11]=2)[CH:3]=1.C([Si](C)(C)[O:40][CH2:41][C:42]#[C:43][CH2:44][NH2:45])(C)(C)C>>[OH:40][CH2:41][C:42]#[C:43][CH2:44][NH:45][C:22](=[O:23])[C:21]1[CH:25]=[CH:26][CH:27]=[CH:28][C:20]=1[NH:19][C:15]1[CH:14]=[C:13]2[C:18]([C:10]([CH:9]=[CH:8][C:4]3[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=3)=[N:11][N:12]2[CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][O:30]2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 22136507HCID 22136507, compoundHCID 693525322-[3-[2-(4-Methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid

Product 1

HCID 69354000HCID 69354000, compound

Procedure

Prepared in a similar manner to that described for Example 6 except using 2-[3-[2-(4-methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid and 4-(tert-Butyl-dimethyl -silanyloxy)-but-2-ynylamine. 1H NMR (CDCl3): δ 9.48 (H, s), 8.46 (1H, d, J=5.3 Hz), 7.92 (1H, d, J=9.0 Hz), 7.83 (1H, d, J=16.2 Hz), 7.52 (1H, d, J=16.6 Hz), 7.46–7.41 (2H, m), 7.34–7.31 (3H, m), 7.12 (1H, dd, J=8.7, 1.9 Hz), 6.99 (1H, d, J=4.9 Hz), 6.81 (1H, t, J=6.8 Hz), 6.40 (1H, t, J=4.9 Hz), 5.62 (1H, dd, J=9.4, 3.0 Hz), 4.28–4.23 (4H, m), 4.08–4.01 (1H, m), 3.76–3.67 (1H, m), 2.63–2.49 (1H, m), 2.38 (3H, s), 2.22–2.06 (2H, m), 1.80–1.60 (3H, m).

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-9ec52910ff704c30a8bf7e8ce30120d5
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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