HRID1827502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22136507

未命名化合物

结构：C[Si](C)(C)CCOCn1nc(C=Nn2cccc2)c2ccc(Nc3ccccc3C(=O)O)cc21

HCID69353167

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCC#CCNC(=O)c1ccccc1Nc1ccc2c(C=Nn3cccc3)nn(COCC[Si](C)(C)C)c2c1

HCID69353748

未命名化合物

PROCEDURE

实验过程

Prepared in a similar manner to that described for Example 6 above except using 2-[3-(Pyrrol-1-yliminomethyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-6-ylamino]-benzoic acid and 4-(tert-Butyl-dimethyl-silanyloxy)-but-2-ynylamine. 1H NMR (DMSO-d6) δ 10.04 (1H, s 9.16 (1H, t, J=5.3 Hz), 9.10 (1H,s), 8.31 (1H, d, J=8.7 Hz), 7.78 (1H, d, J=7.9 Hz), 7.67 (4H, m), 7.49 (1H, t, J=8.5 Hz), 7.24 (1H, dd, J=1.7, 8.7 Hz), 7.03 (1H, t, J=7.4 Hz), 6.33 (2H, t, J=2.3 Hz), 5.85 (2H, s), 4.83 (2H, s), 4.19 (2H, d, J=5.5 Hz), 3.66 (2H, t, J=7.9 Hz), 0.94 (2H, m), 0.89 (9H, s), 0.13 (6H, s), 0.00 (9H, s).

WORKUP

后处理

customPrepared in a similar manner to that

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0a90c28564534d02a1e983020fb51fb6
来源数据集: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07053107B2
来源说明: uspto-grants-2006_05

反应 SMILES

[N:1]1([N:6]=[CH:7][C:8]2[C:16]3[C:11](=[CH:12][C:13]([NH:17][C:18]4[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=4[C:20]([OH:22])=O)=[CH:14][CH:15]=3)[N:10]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:9]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[C:35]([Si:39]([CH3:47])([CH3:46])[O:40][CH2:41][C:42]#[C:43][CH2:44][NH2:45])([CH3:38])([CH3:37])[CH3:36]>>[C:35]([Si:39]([CH3:47])([CH3:46])[O:40][CH2:41][C:42]#[C:43][CH2:44][NH:45][C:20](=[O:22])[C:19]1[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=1[NH:17][C:13]1[CH:12]=[C:11]2[C:16]([C:8]([CH:7]=[N:6][N:1]3[CH:5]=[CH:4][CH:3]=[CH:2]3)=[N:9][N:10]2[CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:32])[CH3:33])=[CH:15][CH:14]=1)([CH3:38])([CH3:37])[CH3:36]