(1,3-Dimethyl-1H-pyrazol-5-yl)methanamine → HCID 69352972, compound

HRID 1827505Notes

Reaction equation

HRID 1827505 reaction equation
[N:1]1([N:6]=[CH:7][C:8]2[C:16]3[C:11](=[CH:12][C:13]([NH:17][C:18]4[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=4[C:20]([OH:22])=O)=[CH:14][CH:15]=3)[N:10]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:9]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH3:35][N:36]1[C:40]([CH2:41][NH2:42])=[CH:39][C:38]([CH3:43])=[N:37]1>>[CH3:35][N:36]1[C:40]([CH2:41][NH:42][C:20](=[O:22])[C:19]2[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=2[NH:17][C:13]2[CH:12]=[C:11]3[C:16]([C:8]([CH:7]=[N:6][N:1]4[CH:2]=[CH:3][CH:4]=[CH:5]4)=[N:9][N:10]3[CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:33])([CH3:32])[CH3:34])=[CH:15][CH:14]=2)=[CH:39][C:38]([CH3:43])=[N:37]1

Participants

3

Reactant 2

HCID 1257670(1,3-Dimethyl-1H-pyrazol-5-yl)methanamineHCID 69353167HCID 69353167, compound

Product 1

HCID 69352972HCID 69352972, compound

Procedure

Prepared in a similar manner to that described for Example 6 above except using 2-[3-(Pyrrol-1-yliminomethyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-6-ylamino]-benzoic acid and C-(2,5-Dimethyl-2H-pyrazol-3-yl)-methylamine. 1H NMR (CDCl3) δ 9.56 (1H, s), 8.68 (1H, s), 8.30 (1H, d, J=8.7 Hz), 7.49 (1H, d, J=8.3 Hz), 7.43 (1H, dd, J=7.9, 1.5 Hz), 7.36–7.31 (2H, m), 7.23 (2H, t, J=2.6 Hz), 7.17 (1H, dd, J=8.7, 1.9 Hz), 6.83 (1H, t, J=7.2 Hz), 6.32 (1H, bt), 6.29 (2H, t, J=2.3 Hz), 6.01 (1H, s), 5.67 (2H, s), 4.61 (2H, d, J=5.6 Hz), 3.60 (3H, s), 3.58 (2H, t, J=8.3 Hz), 2.22 (3H, s), 0.90 (2H, t, J=8.7 Hz), 0.06 (9H, s).

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-161c79645ffc4faebd0d8622b99789ae
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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