Toluene → 4-{6-[8-Cyclopentyl-6-(1-ethoxy-vinyl)-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl}-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][n:16][c:17]([NH:20][c:21]3[n:22][cH:23][c:24]4[c:25]([n:26]3)[n:27]([CH:34]3[CH2:35][CH2:36][CH2:37][CH2:38]3)[c:28](=[O:33])[c:29]([Br:32])[c:30]4[CH3:31])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH2:39]([Sn:40]([CH2:41][CH2:42][CH2:43][CH3:49])([C:44](=[CH2:45])[O:46][CH2:47][CH3:48])[CH2:50][CH2:51][CH2:52][CH3:53])[CH2:54][CH2:55][CH3:56].[CH3:57][c:58]1[cH:59][cH:60][cH:61][cH:62][cH:63]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][n:16][c:17]([NH:20][c:21]3[n:22][cH:23][c:24]4[c:25]([n:26]3)[n:27]([CH:34]3[CH2:35][CH2:36][CH2:37][CH2:38]3)[c:28](=[O:33])[c:29]([C:44](=[CH2:45])[O:46][CH2:47][CH3:48])[c:30]4[CH3:31])[cH:18][cH:19]2)[CH2:12][CH2:13]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-469924ddb42243179a91a787447ced64
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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