Sodium Hydroxide → Cyclohexanecarboxylic Acid (4-hydroxy-benzyl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide

Participants

Reaction Steps

To a solution of toluene-4-sulfonic acid 4-({cyclohexanecarbonyl-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amino}-methyl)-phenyl ester in 5 mL methanol was added 5N NaOH (0.50 mL). The reaction mixture was heated at reflux until complete as judged by TLC and MS. The reaction mixture was washed with methylene chloride. The organic layer was concentrated to afford 0.045 g (41%) of the title compound. MS 423.2 (M+1)+

Provenance & Evidence