Hydrochloric Acid → HCID 22137273, compound

Participants

Reaction Steps

To a solution of crude 2,4,6-trimethyl-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-{1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-ethyl}-benzenesulfonamide (0.071 g, 0.12 mmol) in 4 mL absolute ethanol was added 0.8 mL of 1.2N HCl. The reaction mixture was stirred at room temperature overnight, was diluted with 10 mL saturated aqueous sodium bicarbonate, and the aqueous solution was washed with methylene chloride (3×10 mL). The combined organic layers were dried (sodium sulfate), filtered, and concentrated. The residue was purified by preparative TLC (1.0 mm silica gel layer, elution with 15% methanol/methylene chloride) to afford 0.010 g of N-[1-(4-hydroxy-phenyl)-ethyl]-2,4,6-trimethyl-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-benzenesulfonamide. MS 509.0 (M+1)+

Provenance & Evidence