Triethylamine → HCID 22137460, compound

Participants

Reaction Steps

To a solution of [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-{1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-pentyl}-amine (0.100 g, 0.22 mmol) and triethylamine (0.092 mL, 0.66 mmol) in 2 mL methylene chloride was added hydrocinnamoyl chloride (0.082 mL, 0.55 mmol), dropwise. The reaction mixture was stirred for 1 hr. at room temperature. Saturated aqueous sodium bicarbonate was added and the layers were separated. The aqueous layer was extracted with an additional 2 mL of methylene chloride. The combined organic layers were concentrated to give the title compound of Step A. MS 585.1 (M+1)+

Provenance & Evidence