Hydrochloric Acid → HCID 22137409, compound

Participants

Reaction Steps

To a solution of 2-chloro-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-{1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-ethyl}-benzenesulfonamide (0.088 g, 0.150 mmol) in absolute ethanol (4.0 mL) was added HCl (1.2N, 0.8 mL). The reaction was stirred at room temperature overnight. The reaction mixture was quenched with sat. sodium bicarbonate solution (ca. 10 mL) and extracted with methylene chloride (2×10 mL). The combined organic layers were dried (sodium sulfate), filtered and concentrated. The residue was purified by preparative TLC (SiO2, 10% methanol/ethyl acetate) to afford the title compound (0.007 g, 14.6 μmol). MS 501.4 (M+1)+

Provenance & Evidence