Hydrochloric Acid → HCID 22137278, compound

Participants

Reaction Steps

To a solution of N-(4-iodo-phenyl)-2,4,6-trimethyl-N-[3-(tetrahydro-pyran-2-yloxy)-benzyl]-benzenesulfonamide (0.506 g, 0.86 mmol) in 5 mL tetrahydrofuran was added HCl (5.35 mL of a 4.0 M solution in 1,4-dioxane, 21.4 mmol) and triethylsilane (1.37 mL, 8.56 mmol). The reaction mixture was stirred at room temperature overnight. Saturated aqueous sodium bicarbonate was added and the mixture was extracted with methylene chloride. The organic layer was separated and concentrated. Medium pressure silica gel chromatography of the residue (methylene chloride) afforded 0.36 g (83%) of the title compound of Step C.

Provenance & Evidence